Article
Human polyomavirus JC control region variants in persistently infected CNS and kidney tissue.
The Journal of general virology - 1 Apr 1998
Elsner C, Dörries K
Abstract excerpt
The question of a possible role for JC virus (JCV) genomic rearrangements in the pathogenesis of progressive multifocal leukoencephalopathy (PML) was addressed by analysis of the genomic complexity and the transcriptional control region (TCR) of the JCV DNA population in persistently infected CNS and kidney tissue. After cloning of full-length viral DNA, no extensive changes were detected in the coding regions of...
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