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Article

Hyperactivity of Human DNase I Variants

1 May 1998

Abstract excerpt

Human DNase I, an enzyme used to treat cystic fibrosis patients, has been engineered to more effectively degrade double-stranded DNA to lower molecular weight forms by introducing positively charged amino acids at positions that can interact favorably with the proximal negatively charged phosphate groups of the DNA. A series of combination mutants having from one to six additional basic residues compared with the...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 9565591
DOI: 10.1074/jbc.273.19.11701

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