Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Secreted amyloid precursor protein and holo-APP bind amyloid beta through distinct domains eliciting different toxic responses on hippocampal neurons.

Journal of neuroscience research - 1 Jun 2010

Kedikian Gabriela, Heredia Florencia, Salvador Victoria Rozes, Raimunda Daniel, Isoardi Nora, Heredia Lorena, Lorenzo Alfredo

Abstract excerpt

Amyloid beta (Abeta) is a metabolic product of Abeta precursor protein (APP). Deposition of Abeta in the brain and neuronal degeneration are characteristic hallmarks of Alzheimer's disease (AD). Abeta induces neuronal degeneration, but the mechanism of neurotoxicity remains elusive. Increasing ev...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetinae

Share to Cricetulus

Share to Embryo, Mammalian

Share to Hippocampus

Share to Immunoprecipitation

Share to Peptide Fragments

Source

Identifiers

PMID: 20155808
DOI: 10.1002/jnr.22347

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20155808-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Secreted amyloid precursor protein and holo-APP bind amyloid beta through distinct domains eliciting different toxic responses on hippocampal neurons.PMID 20155808Read ↗

The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?Semantic proximity Read ↗

Cellular functions of the amyloid precursor protein from development to dementia.Semantic proximity Read ↗

The amyloid precursor protein: beyond amyloid.Semantic proximity Read ↗

Engineered APP C-terminus Alters APP Expression Dynamics in Differentiated SH-SY5Y- Derived NeuronsSemantic proximity Read ↗

Current and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysSemantic proximity Read ↗

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives.Semantic proximity Read ↗

Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.Semantic proximity Read ↗

Cellular mechanisms of beta-amyloid production and secretion.Semantic proximity Read ↗

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognitionSemantic proximity Read ↗

Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.Semantic proximity Read ↗

Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.Semantic proximity Read ↗

The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.