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Article

D1 dopamine receptor activity is not altered by a mutation in the first intracellular loop.

Biochimica et biophysica acta - 27 Mar 1998

Jin H, Nip S, O'Dowd B F, George S R

Abstract excerpt

The first intracellular loop of the G protein-coupled receptors (GPCRs) is probably the domain that has been studied least. According to the limited data available, mutations of this region can increase, decrease or not affect receptor-G protein coupling, depending on the receptor. Melanocyte-stimulating hormone (MSH) receptors with a Ser69Leu mutation of the first intracellular loop phenotypically confer tobacco...

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Identifiers

PMID: 9561802
DOI: 10.1016/s0167-4889(97)00159-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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