Article
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
The EMBO journal - 1 May 1995
Paonessa G, Graziani R, De Serio A, Savino R, Ciapponi L, Lahm A, Salvati A L, Toniatti C, Ciliberto G
Abstract excerpt
The helical cytokine interleukin (IL) 6 and its specific binding subunit IL-6R alpha form a 1:1 complex which, by promoting homodimerization of the signalling subunit gp130 on the surface of target cells, triggers intracellular responses. We expressed differently tagged forms of gp130 and used them in solution-phase binding assays to show that the soluble extracellular domains of gp130 undergo dimerization in the...
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