Article
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
The EMBO journal - 1 May 1995
Paonessa G, Graziani R, De Serio A, Savino R, Ciapponi L, Lahm A, Salvati A L, Toniatti C, Ciliberto G
Abstract excerpt
The helical cytokine interleukin (IL) 6 and its specific binding subunit IL-6R alpha form a 1:1 complex which, by promoting homodimerization of the signalling subunit gp130 on the surface of target cells, triggers intracellular responses. We expressed differently tagged forms of gp130 and used th...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- Binding Sites
- Cell Line
- Cytokine Receptor gp130
- Genetic Variation
- Humans
- Interleukin-6
- Membrane Glycoproteins
- Models, Molecular
- Molecular Sequence Data
- Protein Conformation
- Receptors, Interleukin
- Receptors, Interleukin-6
- Signal Transduction