Article
Mutational inactivation of aminoacylase-I in a small cell lung cancer cell line.
Genes, chromosomes & cancer - 1 Apr 1998
Cook R M, Franklin W A, Moore M D, Johnson B E, Miller Y E
Abstract excerpt
Small cell lung cancer (SCLC) cell lines and tumors invariably exhibit loss of heterozygosity (LOH) or, in rare cases, homozygous deletions involving part or all of chromosome arm 3p, suggesting the presence of 1 or more tumor-suppressor genes in this region. The gene encoding aminoacylase-I (ACYl) is localized on chromosome segment 3p21.1. ACYl enzymatic activity, protein, and mRNA have been demonstrated to be...
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