Article
Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Apr 2010
van Doorninck John A, Ji Lingyun, Schaub Betty, Shimada Hiroyuki, Wing Michele R, Krailo Mark D, Lessnick Stephen L, Marina Neyssa, Triche Timothy J, Sposto Richard, Womer Richard B, Lawlor Elizabeth R
Abstract excerpt
PURPOSE Ewing sarcoma family tumors (ESFTs) exhibit chromosomal translocations that lead to the creation of chimeric fusion oncogenes. Combinatorial diversity among chromosomal breakpoints produces varying fusions. The type 1 EWS-FLI1 transcript is created as a result of fusion between exons 7 of EWS and 6 of FLI1, and retrospective studies have reported that type 1 tumors are associated with an improved outcome....
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