Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor

Abstract excerpt

Activation of complement gene expression plays a major role in the response to antigenic challenge. The induction of complement synthesis occurs primarily in liver and in macrophages and is mediated, at least in part, by increased transcription of the complement genes. For example, transcription of the C4 complement gene, which plays a crucial role in the complement pathway, is induced in response to acute...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Complement system in diseases
• Share to Erythrocyte Function and Pathophysiology
• Share to Reproductive System and Pregnancy