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Article

Role of MDM2 Overexpression in Doxorubicin Resistance of Breast Carcinoma

1 Feb 1998

Abstract excerpt

Several oncoproteins or tumor suppressor gene products have been indicated to be of value as predictors of the de novo resistance to cytotoxic agents. In this study, we have investigated the role of MDM2 (murine double minutes) overexpression in doxorubicin resistance of breast cancer. Immunocytochemical analysis demonstrated that MDM2-positive tumors, even with p53-negative phenotype, were significantly more...

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Identifiers

PMID: 9548451
DOI: 10.1111/j.1349-7006.1998.tb00552.x

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