Scattered micrometastases visualized at the single-cell level: detection and re-isolation of lacZ-labeled metastasized lymphoma cells.

doi:10.1002/ijc.2910580222

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Article

Scattered micrometastases visualized at the single-cell level: detection and re-isolation of lacZ-labeled metastasized lymphoma cells.

International journal of cancer - 15 Jul 1994

Krüger A, Schirrmacher V, von Hoegen P

Abstract excerpt

To study metastasis at the single-cell level we transduced highly metastatic ESb lymphoma cells with a retroviral expression vector containing the lacZ (bacterial beta-galactosidase) gene. This allowed single ESb-lacZ tumor cells to be detected in infiltrated target organs by means of X-Gal stain...

Topics

Animals
Antigens, Neoplasm
Blotting, Southern
Cell Division
Cell Survival
Clone Cells
Epitopes
Flow Cytometry
Immunocompromised Host
Lac Operon
Liver Neoplasms
Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred DBA

Models, Biological

Phenotype

T-Lymphocytes, Cytotoxic

Transfection

Source

Open in PubMed

Identifiers

PMID: 7517921
DOI: 10.1002/ijc.2910580222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7517921-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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