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Article

Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice

28 Mar 2003

Abstract excerpt

Extraocular muscle (EOM) is spared in Duchenne muscular dystrophy. Here, we tested putative EOM sparing mechanisms predicted from existing dystrophinopathy models. Data show that mdx mouse EOM contains dystrophin-glycoprotein complex (DGC)-competent and DGC-deficient myofibers distributed in a fiber type-specific pattern. Up-regulation of a dystrophin homologue, utrophin, mediates selective DGC retention. Counter...

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PMID: 12670877
DOI: 10.1096/fj.02-0810fje

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