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Article

N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice.

The Journal of physiology - 1 Apr 2008

Whitehead Nicholas P, Pham Catherine, Gervasio Othon L, Allen David G

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by a mutation in the gene encoding dystrophin, a protein linking the cytoskeleton to the extracellular matrix. In this study we investigated whether the antioxidant N-acetylcysteine (NAC) provided protection against dystrophic muscle damage in the mdx mouse, an animal model of DMD. In isolated mdx muscles, NAC prevented the increased...

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Source

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Identifiers

PMID: 18258657
DOI: 10.1113/jphysiol.2007.148338
PMCID: PMC2375717

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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