Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.

1 May 1994

Abstract excerpt

The complement receptor type 1 (CR1; CD35), carrying 30 short consensus repeats (SCRs), has two sites. Site 1 contains SCR-1 and SCR-2 and binds C4b. Site 2 contains SCR-8 and SCR-9 and was reported to bind mainly C3b (Klickstein, L. B., Bartow, T. J., Miletic, V., Rabson, L. D., Smith, J. A., and Fearon, D. T. (1988) J. Exp. Med. 168, 1699-1717). For the functional analysis we used two constructs, each with one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Monoclonal and Polyclonal Antibodies Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8175757
DOI: 10.1016/s0021-9258(17)36829-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.PMID 8175757Read ↗

Structure-Function Analysis of the Active Sites of Complement Receptor Type 1Semantic proximity Read ↗

Structure–function relationships of complement receptor type 1Semantic proximity Read ↗

A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding.Semantic proximity Read ↗

The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35).Semantic proximity Read ↗

A soluble deletion mutant of the human complement receptor type 1, which lacks the C4b binding site, is a selective inhibitor of the alternative complement pathway.Semantic proximity Read ↗

Structural and functional correlation of the human complement receptor type 1.Semantic proximity Read ↗

Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement PathwaySemantic proximity Read ↗

Synergy between two active sites of human complement receptor type 1 (CD35) in complement regulation: implications for the structure of the classical pathway C3 convertase and generation of more potent inhibitors.Semantic proximity Read ↗

Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1qSemantic proximity Read ↗

Mechanistic insights into complement pathway inhibition by CR1 domain duplicationSemantic proximity Read ↗

Structure of the C3b Binding Site of CR1 (CD35), the Immune Adherence ReceptorSemantic proximity Read ↗

Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.