Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically Modified Human Keratinocytes Overexpressing PDGF-A Enhance the Performance of a Composite Skin Graft

1 Mar 1998

Abstract excerpt

Skin loss due to burns and ulcers is a major medical problem. Bioengineered skin substitutes that use cultured keratinocytes as an epidermal layer with or without analogues of the dermis are one strategy for skin repair. However, none can achieve definitive wound closure, function, or cosmesis comparable to split-thickness autografts. Moreover, autograft donor sites, which require time to heal, may be limited or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Electrospun Nanofibers in Biomedical Applications
Share to Wound Healing and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9525314
DOI: 10.1089/hum.1998.9.4-529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically Modified Human Keratinocytes Overexpressing PDGF-A Enhance the Performance of a Composite Skin GraftPMID 9525314Read ↗

Genetically Modified Human Epidermis Overexpressing PDGF-A Directs the Development of a Cellular and Vascular Connective Tissue Stroma When Transplanted to Athymic Mice–Implications for the Use of Genetically Modified Keratinocytes to Modulate Dermal RegenerationSemantic proximity Read ↗

Adult Human Dermal Progenitor Cell Transplantation Modulates the Functional Outcome of Split-Thickness Skin Xenografts.Semantic proximity Read ↗

Efficacy and Safety of Viable Selective Germline Genome Edited Pigs Skin Xenotransplants in Patients with Thermal BurnsSemantic proximity Read ↗

FGF-7 Expression Enhances the Performance of Bioengineered SkinSemantic proximity Read ↗

Electrically Activated Primary Human Fibroblasts Improve In Vitro and In Vivo Skin Regeneration.Semantic proximity Read ↗

Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting.Semantic proximity Read ↗

Permanent skin replacement using engineered epidermis containing fewer than 5% syngeneic keratinocytes.Semantic proximity Read ↗

Regulation of the spatial organization of mesenchymal connective tissue: effects of cell-associated versus released isoforms of platelet-derived growth factor.Semantic proximity Read ↗

Lentiviral Transfection with the PDGF-B Gene Improves Diabetic Wound HealingSemantic proximity Read ↗

Software development for autologous skin substitute productionSemantic proximity Read ↗

Keratinocyte regulation of TGF‐β and connective tissue growth factor expression: A role in suppression of scar tissue formationSemantic proximity Read ↗

Keratinocytes modulate the biosynthetic phenotype of dermal fibroblasts at a pretranslational level in a human skin equivalent.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.