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FGF-7 Expression Enhances the Performance of Bioengineered Skin

15 Jun 2004

Abstract excerpt

To improve the performance of bioengineered skin, we used a recombinant retrovirus encoding FGF-7 to modify diploid human keratinocytes genetically. Control or FGF-7-expressing keratinocytes were seeded onto acellular human dermis to form bioengineered skin. Gene-modified skin secreted significant levels of FGF-7 and formed a thicker and hyperproliferative epidermis with about four times the number of cells per...

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PMID: 15233944
DOI: 10.1016/j.ymthe.2004.04.013

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