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Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients.

Cancer research - 15 Oct 1996

Chidambaram A, Goldstein A M, Gailani M R, Gerrard B, Bale S J, DiGiovanna J J, Bale A E, Dean M

Abstract excerpt

The nevoid basal cell carcinoma syndrome (NBCCS), or Gorlin syndrome, is a multisystem autosomal dominant disorder. The salient features of this syndrome include multiple basal cell carcinomas, palmar and/or plantar pits, odontogenic keratocysts, skeletal and developmental anomalies, and ectopic calcification. Other features include such tumors as ovarian fibromas and medulloblastomas. There is extensive...

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PMID: 8840969

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Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients.PMID 8840969Read ↗

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.Semantic proximity Read ↗

Molecular characterization of Italian nevoid basal cell carcinoma syndrome patients.Semantic proximity Read ↗

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.Semantic proximity Read ↗

Identification of Mutations in the Human PATCHED Gene in Sporadic Basal Cell Carcinomas and in Patients with the Basal Cell Nevus SyndromeSemantic proximity Read ↗

Mutations in the human homologue of Drosophila patched in Japanese nevoid basal cell carcinoma syndrome patients.Semantic proximity Read ↗

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.Semantic proximity Read ↗

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours.Semantic proximity Read ↗

Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident.Semantic proximity Read ↗

Multifocal desmoplastic medulloblastoma in an african-american child with nevoid basal cell carcinoma (gorlin) syndrome. Case report.Semantic proximity Read ↗

Mutations in the human homologue of the Drosophila patched gene in esophageal squamous cell carcinoma.Semantic proximity Read ↗

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