Article
Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes.
The Journal of investigative dermatology - 1 Feb 2005
Bigelow Rebecca L H, Jen Emily Y, Delehedde Maryse, Chari Nikhil S, McDonnell Timothy J
Abstract excerpt
The deregulation of the sonic hedgehog (shh) signaling pathway in epidermal keratinocytes is a primary event leading to the formation of basal cell carcinoma (BCC). The mechanisms by which this pathway exerts this effect remain largely undefined. We demonstrate that overexpression of shh in HaCaT keratinocytes grown in organotypic cultures induced a basal cell phenotype, as evidenced by their morphology,...
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