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Elevated furin expression in aggressive human head and neck tumors and tumor cell lines

1 Aug 2001

Abstract excerpt

Pro-protein convertases (PCs) are proteases that recognize and cleave precursor proteins. Furin, a well-studied PC, is ubiquitously expressed, and it has been implicated in many physiological and pathological processes. Some substrates for furin, such as membrane type 1 (MT1) matrix metalloproteinase (MMP), an MMP that activates gelatinase, a collagen-degrading enzyme, are associated with the advanced malignant...

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PMID: 11536372
DOI: 10.1002/mc.1057

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