Article
Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis.
Toxicology - 3 Aug 2009
Sun Yang, Pi Jingbo, Wang Xueqian, Tokar Erik J, Liu Jie, Waalkes Michael P
Abstract excerpt
Inorganic arsenic is a known human skin carcinogen. Chronic arsenic exposure results in various human skin lesions, including hyperkeratosis and squamous cell carcinoma (SCC), both characterized by distorted cytokeratin (CK) production. Prior work shows the human skin keratinocyte HaCaT cell line, when exposed chronically for >25 weeks to a low level of inorganic arsenite (100nM) results in cells able to produce...
Topics
- Arsenites
- Biomarkers, Tumor
- Carcinogens
- Cell Line
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Humans
- Keratinocytes
- Keratins
- Membrane Proteins
- Phenotype
- Skin Neoplasms
- Tumor Stem Cell Assay