In vitro selection of Haemonchus contortus for benzimidazole resistance reveals a mutation at amino acid 198 of beta-tubulin.

doi:10.1016/j.molbiopara.2009.07.002

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Article

In vitro selection of Haemonchus contortus for benzimidazole resistance reveals a mutation at amino acid 198 of beta-tubulin.

Molecular and biochemical parasitology - 1 Nov 2009

Rufener Lucien, Kaminsky Ronald, Mäser Pascal

Abstract excerpt

Benzimidazoles were the first broad-spectrum anthelmintics and are still in use today against gastro-intestinal nematodes of ruminants such as Haemonchus contortus. Benzimidazoles block the polymerization of nematode microtubules. However, their efficacy is jeopardized by the spread of drug-resistant parasites that carry point mutations in beta-tubulin. Here we use a novel in vitro selection-in vivo propagation...

Topics

Alleles
Amino Acid Substitution
Animals
Anthelmintics
DNA, Helminth
Drug Resistance
Haemonchus
Ivermectin
Molecular Sequence Data
Mutation, Missense
Polymerase Chain Reaction
Selection, Genetic
Sequence Analysis, DNA
Thiabendazole
Tubulin

Source

Open in PubMed

Identifiers

PMID: 19616042
DOI: 10.1016/j.molbiopara.2009.07.002

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