Article
Expression of factor I-resistant mutants of the human complement component C3 in heterologous systems.
Xenotransplantation - 1 Feb 1998
Fecke W, Farries T C, D'Cruz L G, Napper C M, Harrison R A
Abstract excerpt
Complement plays a major role in hyperacute rejection of xenografts. In order to overcome this, we are developing, by minimal mutagenesis, a modified C3 molecule that, like cobra venom factor (CVF), escapes normal complement regulatory processes and inhibits complement-mediated responses by syste...
Topics
- Animals
- Baculoviridae
- CHO Cells
- COS Cells
- Complement C3
- Cricetinae
- Fibrinogen
- Gene Expression
- Graft Rejection
- Guinea Pigs
- Humans
- Mutagenesis, Site-Directed
- Mutation
- Protein Engineering
- Recombinant Proteins
- Transfection
- Transplantation, Heterologous