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Article

Recombinant complement receptor 2 radiolabeled with [99mTc(CO)3]+: a potential new radiopharmaceutical for imaging activated complement.

PloS one - 6 Apr 2011

Badar Adam, DeFreitas Sarah, McDonnell James M, Yahya Norhakim, Thakor David, Razavi Reza, Smith Richard, Sacks Steven, Mullen Gregory E D

Abstract excerpt

We describe the design and synthesis of a new Tc-99m labeled bioconjugate for imaging activated complement, based on Short Consensus Repeats 1 and 2 of Complement Receptor 2 (CR2), the binding domain for C3d. To avoid non specific modification of CR2 and the potential for modifying lysine residues critical to the CR2/C3d contact surface, we engineered a new protein, recombinant CR2 (rCR2), to include the...

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PMID: 21494666
DOI: 10.1371/journal.pone.0018275
PMCID: PMC3071809

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Source receipt: pubmed, retrieved 7 Sept 2026.

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