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Article

A Dominant Negative Isoform of the Long QT Syndrome 1 Gene Product

1 Mar 1998

Abstract excerpt

Mutations in the KvLQT1 gene are the cause of the long QT syndrome 1. KvLQT1 gene product is associated with the regulator protein IsK to produce a component of the delayed rectifier K+ current in cardiac myocytes. We identified an N-terminal truncated isoform of the KvLQT1 gene product, referred to as isoform 2. In RNase protection assays, isoform 2 represented 28.1 +/- 0.6% of the total KvLQT1 expression in the...

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PMID: 9506986
DOI: 10.1074/jbc.273.12.6837

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