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Article

Identification of Kv11.1 isoform switch as a novel pathogenic mechanism of long-QT syndrome.

Circulation. Cardiovascular genetics - 1 Aug 2014

Gong Qiuming, Stump Matthew R, Deng Vivianne, Zhang Li, Zhou Zhengfeng

Abstract excerpt

BACKGROUND: The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. The relative expression of the full-length Kv11.1a isoform and the C-terminally truncated Kv11.1a-USO isoform plays an important role in regulation of channel function. The formation of C-terminal isoforms is determined by competition between the splicing and alternative...

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Source

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Identifiers

PMID: 25028483
DOI: 10.1161/CIRCGENETICS.114.000586
PMCID: PMC4180443

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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