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Article

Differential expression of KvLQT1 isoforms across the human ventricular wall

1 Jun 2000

Abstract excerpt

Long Q-T mutant (KvLQT1) K(+) channels associate with their regulatory subunit IsK to produce the slow component of the delayed rectifier potassium (I(Ks)) cardiac current. The amplitude of KvLQT1 current depends on the expression of a KvLQT1 splice variant (isoform 2) that exerts strong dominant negative effects on the full-length KvLQT1 protein (isoform 1). We used RNase protection assays to determine the...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 10843888
DOI: 10.1152/ajpheart.2000.278.6.h1908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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