Article
Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group.
The Journal of clinical endocrinology and metabolism - 1 May 1996
Frank-Raue K, Höppner W, Frilling A, Kotzerke J, Dralle H, Haase R, Mann K, Seif F, Kirchner R, Rendl J, Deckart H F, Ritter M M, Hampel R, Klempa J, Scholz G H, Raue F
Abstract excerpt
It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome. In particular, individuals with a Cys634-Arg substitution should have a gre...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Medullary
- Codon
- Drosophila Proteins
- Exons
- Genotype
- Germany
- Molecular Sequence Data
- Multiple Endocrine Neoplasia
- Multiple Endocrine Neoplasia Type 2a
- Mutation
- Phenotype