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Article

Difference in development of medullary thyroid carcinoma among carriers of RET mutations in codons 790 and 791.

Clinical endocrinology - 1 Aug 2008

Frank-Raue Karin, Machens Andreas, Scheuba Christian, Niederle Bruno, Dralle Henning, Raue Friedhelm

Abstract excerpt

OBJECTIVES: Hereditary medullary thyroid carcinoma (MTC) is caused by germ-line mutations in the RET proto-oncogene. Our study addresses the difference in development of MTC between rare mutations in RET codons 790, 791 and 804. DESIGN: We evaluated tumour stage, calcitonin levels, biochemical cure rates and associated endocrinopathies in 153 German/Austrian patients with RET 790 (n = 47), 791 (n = 56) and 804...

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Identifiers

PMID: 18248648
DOI: 10.1111/j.1365-2265.2008.03215.x

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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