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Article

Parallel pathways in the folding of a short-term denatured scFv fragment of an antibody.

Folding & design - 1 Jan 1998

Freund C, Gehrig P, Baici A, Holak T A, Plückthun A

Abstract excerpt

BACKGROUND: Antibodies are prototypes of multimeric proteins and consist of structurally similar domains. The two variable domains of an antibody (VH and VL) interact through a large hydrophobic interface and can be expressed as covalently linked single-chain Fv (scFv) fragments. The in vitro folding of scFv fragments after long-term denaturation in guanidinium chloride is known to be slow. In order to delineate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9502319
DOI: 10.1016/S1359-0278(98)00007-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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