Article
Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 1998
Acland G M, Ray K, Mellersh C S, Gu W, Langston A A, Rine J, Ostrander E A, Aguirre G D
Abstract excerpt
Progressive rod-cone degeneration (prcd) is the most widespread hereditary retinal disease leading to blindness in dogs and phenotypically is the canine counterpart of retinitis pigmentosa (RP) in humans. In previous efforts to identify the genetic locus for prcd, the canine homologs for many of the genes causally associated with RP in humans, such as RHO, PDE6B, and RDS/peripherin, have been excluded. In...
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