Article
Canine RD3 mutation establishes rod-cone dysplasia type 2 (rcd2) as ortholog of human and murine rd3.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2009
Kukekova Anna V, Goldstein Orly, Johnson Jennifer L, Richardson Malcolm A, Pearce-Kelling Susan E, Swaroop Anand, Friedman James S, Aguirre Gustavo D, Acland Gregory M
Abstract excerpt
Rod-cone dysplasia type 2 (rcd2) is an autosomal recessive disorder that segregates in collie dogs. Linkage disequilibrium and meiotic linkage mapping were combined to take advantage of population structure within this breed and to fine map rcd2 to a 230-kb candidate region that included the gene C1orf36 responsible for human and murine rd3, and within which all affected dogs were homozygous for one haplotype. In...
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