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Article

Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1992

McNearney T, Hornickova Z, Markham R, Birdwell A, Arens M, Saah A, Ratner L

Abstract excerpt

V3 envelope sequences were determined from amplified human immunodeficiency virus type 1 (HIV-1) sequences of uncultivated leukocytes obtained sequentially from four infected adults over the course of infection. Lower levels of sequence heterogeneity were noted in samples obtained early in HIV-1 infection, prior to CD4 depletion, than in samples obtained at later times during disease. The pattern of amino acid...

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Identifiers

PMID: 1438212
DOI: 10.1073/pnas.89.21.10247
PMCID: PMC50315

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