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Article

Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy.

Journal of virology - 1 Mar 1998

Günthard H F, Wong J K, Ignacio C C, Guatelli J C, Riggs N L, Havlir D V, Richman D D

Abstract excerpt

Potent antiretroviral therapy can reduce human immunodeficiency virus (HIV) in plasma to levels below the limit of detection for up to 2 years, but the extent to which viral replication is suppressed is unknown. To search for ongoing viral replication in 10 patients on combination antiretroviral therapy for up to 1 year, the emergence of genotypic drug resistance across different compartments was studied and...

Topics

Amino Acid Sequence
Base Sequence
DNA, Viral
Drug Resistance, Microbial
Drug Resistance, Multiple
Drug Therapy, Combination
Genotype
HIV Infections
HIV Protease
HIV Reverse Transcriptase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV-1

Humans

Indinavir

Lamivudine

Lymph Nodes

Molecular Sequence Data

Mutation

RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 9499103
DOI: 10.1128/JVI.72.3.2422-2428.1998
PMCID: PMC109542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9499103-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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