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Article

Expression of Cytochrome P450 Genes Encoding Enzymes Active in the Metabolism of Tamoxifen in Human Uterine Endometrium

1 Feb 1998

Abstract excerpt

Long-term tamoxifen therapy is associated with increased risk of uterine endometrial cancer and benign alterations. Tamoxifen is metabolized to reactive intermediates by endometrial tissue, and tamoxifen therapy-induced DNA adducts have been found in human endometrium. Since metabolic activation is often catalyzed by cytochrome P450 (CYP) enzymes, the expression profile of individual xenobiotic-metabolizing CYP...

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PMID: 9498238
DOI: 10.1111/j.1600-0773.1998.tb01404.x

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