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Article

Amplification and overexpression of theAKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 Feb 1998

Abstract excerpt

AKT2, an oncogene encoding a protein serine-threonine kinase implicated in phosphatidylinositol-3-OH kinase signaling, is amplified in some human ovarian and pancreatic carcinomas. We previously demonstrated that the tumorigenicity and invasiveness of pancreatic ductal adenocarcinoma (PDAC) cell lines with amplified AKT2 could be markedly reduced by transfection with antisense AKT2 constructs. To evaluate further...

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PMID: 9496907
DOI: 10.1002/(sici)1098-2744(199802)21:2<81::aid-mc1>3.0.co;2-r

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