Article
[Alteration of genomic structure and/or expression of cancer associated genes in hepatocellular carcinoma].
Rinsho byori. The Japanese journal of clinical pathology - 1 Jan 1998
Fujimoto Y, Kohgo Y
Abstract excerpt
Cancer is thought to arise from the accumulation of several genetic mutations in a single cell. These include integration of viral genomes, activation of protooncogenes and inactivation of tumor suppressor genes. HCC is one of the most common cancers in Asia and Africa. Various studies have revealed its association with hepatitis B or C viral infection. While activation of known protooncogenes, such as ras genes...
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