Article
A cell culture model for androgen effects in motor neurons.
Journal of neurochemistry - 1 Mar 1998
Brooks B P, Merry D E, Paulson H L, Lieberman A P, Kolson D L, Fischbeck K H
Abstract excerpt
Androgens are known to alter the morphology, survival, and axonal regeneration of lower motor neurons in vivo. To understand better the molecular mechanisms of androgen action in neurons, we created a model system by stably expressing the human androgen receptor (AR) in motor neuron hybrid cells. Motor neuron hybrid cells express markers consistent with anterior horn cells and can be differentiated into a...
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