Article
Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes.
FEMS microbiology letters - 1 Feb 1998
Watts H J, Cheah F S, Hube B, Sanglard D, Gow N A
Abstract excerpt
The aspartate proteinase inhibitor pepstatin A has been shown previously to reduce the adherence of Candida albicans yeast cells to human surfaces. This suggests that in addition to their presumed function facilitating tissue penetration, the secreted aspartate proteinases (Saps) of this fungal pathogen may have auxiliary roles as cellular adhesins. We therefore examined the relative adherence of yeast cells of a...
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