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Article

Chromosomal autonomy of hMLH1 methylation in colon cancer.

Oncogene - 21 Feb 2002

Li Hui, Myeroff Lois, Kasturi Lakshmi, Krumroy Lisa, Schwartz Stuart, Willson James K V, Stanbridge Eric, Casey Graham, Markowitz Sanford

Abstract excerpt

Silencing of hMLH1 expression by aberrant hMLH1 promoter methylation accounts for the majority of sporadic colon cancers with microsatellite instability. We have previously shown hMLH1 silencing is biallelic and actively maintained. To study the mechanism of aberrant hMLH1 methylation, we assayed whether an hMLH1 methylated cell could transfer methylation and silencing to an exogenous hMLH1 promoter in somatic...

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Identifiers

PMID: 11857087
DOI: 10.1038/sj.onc.1205247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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