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Article

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.

Molecular and cellular biology - 1 Aug 2005

Kamada Yoshiaki, Fujioka Yuko, Suzuki Nobuo N, Inagaki Fuyuhiko, Wullschleger Stephan, Loewith Robbie, Hall Michael N, Ohsumi Yoshinori

Abstract excerpt

The target of rapamycin (TOR) protein kinases, Tor1 and Tor2, form two distinct complexes (TOR complex 1 and 2) in the yeast Saccharomyces cerevisiae. TOR complex 2 (TORC2) contains Tor2 but not Tor1 and controls polarity of the actin cytoskeleton via the Rho1/Pkc1/MAPK cell integrity cascade. Substrates of TORC2 and how TORC2 regulates the cell integrity pathway are not well understood. Screening for multicopy...

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Identifiers

PMID: 16055732
DOI: 10.1128/MCB.25.16.7239-7248.2005
PMCID: PMC1190227

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.PMID 16055732Read ↗

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TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.Semantic proximity Read ↗

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

TOR2 is required for organization of the actin cytoskeleton in yeast.Semantic proximity Read ↗

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