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Article

Identification of a silencing element in the human 15q11-q13 imprinting center by using transgenic Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 1998

Lyko F, Buiting K, Horsthemke B, Paro R

Abstract excerpt

Prader-Willi syndrome (PWS) and Angelman syndrome are neurogenetic disorders caused by the lack of a paternal or a maternal contribution from human chromosome 15q11-q13, respectively. Deletions in the transcription unit of the imprinted SNRPN gene have been found in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain. It has been suggested that the...

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Source

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Identifiers

PMID: 9465079
DOI: 10.1073/pnas.95.4.1698
PMCID: PMC19156

Genes

SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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