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Towards a molecular understandingof Prader-Willi and Angelman syndromes

1 Sept 1999

Abstract excerpt

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are two distinct neurological disorders that map to human chromosome 15q11-q13 and involve perturbations of imprinted gene expression. PWS is caused by a deficiency of paternal gene expression and AS is caused by a deficiency of maternal gene expression. Experiments in the last year have focused on molecular analysis of the human chromosomal region as well as...

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PMID: 10469839
DOI: 10.1093/hmg/8.10.1867

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