Genomic imprinting: potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes.

doi:10.1093/molehr/3.4.321

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Article

Genomic imprinting: potential function and mechanisms revealed by the Prader-Willi and Angelman syndromes.

Molecular human reproduction - 1 Apr 1997

Glenn C C, Driscoll D J, Yang T P, Nicholls R D

Abstract excerpt

The Prader-Willi (PWS) and Angelman (AS) syndromes are two clinically distinct syndromes which result from lack of expression of imprinted genes within chromosome 15q11-q13. These two syndromes result from 15q11-q13 deletions, chromosome 15 uniparental disomy (UPD), imprinting centre mutations an...

Topics

Angelman Syndrome
Animals
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 15
DNA Methylation
Female
Gene Expression
Genomic Imprinting
Humans
Male
Mice
Mutation
Paternity
Phenotype
Prader-Willi Syndrome

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