Structure and function of the human chromosome 15 imprinting center.

doi:10.1002/(SICI)1097-4652(199711)173:2<237::AID-JCP28>3.0.CO;2-B

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Article

Structure and function of the human chromosome 15 imprinting center.

Journal of cellular physiology - 1 Nov 1997

Horsthemke B

Abstract excerpt

The Prader-Willi syndrome (PWS) and the Angelman syndrome (AS) are distinct neurogenetic disorders that are caused by a deficiency of paternal (PWS) or maternal (AS) contributions to chromosome 15. The affected genes are located in an imprinted chromosomal domain of 2 Mb, which is controlled by a...

Topics

Angelman Syndrome
Chromatin
Chromosomes, Human, Pair 15
DNA Methylation
Gene Deletion
Humans
Imprinting, Psychological
Mutation
Prader-Willi Syndrome

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