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Article

Structure and function of the human chromosome 15 imprinting center.

Journal of cellular physiology - 1 Nov 1997

Horsthemke B

Abstract excerpt

The Prader-Willi syndrome (PWS) and the Angelman syndrome (AS) are distinct neurogenetic disorders that are caused by a deficiency of paternal (PWS) or maternal (AS) contributions to chromosome 15. The affected genes are located in an imprinted chromosomal domain of 2 Mb, which is controlled by an imprinting center (IC). The IC has been mapped to a 100-kb region including the SNRPN gene and appears to have a...

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Source

Identifiers

PMID: 9365529
DOI: 10.1002/(SICI)1097-4652(199711)173:2<237::AID-JCP28>3.0.CO;2-B

Genes

SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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