Article
Molecular Cloning and Functional Expression of Mannitol-1-phosphatase from the Apicomplexan Parasite Eimeria tenella
1 Feb 1998
Abstract excerpt
A metabolic pathway responsible for the biosynthesis and utilization of mannitol is present in the seven species of Eimeria that infect chickens, but is not in the avian host. Mannitol-1-phosphatase (M1Pase), a key enzyme for mannitol biosynthesis, is a highly substrate-specific phosphatase and, accordingly, represents an attractive chemotherapeutic target. Amino acid sequence of tryptic peptides obtained from...
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