Article
Detection of TP53 mutation, loss of heterozygosity and DNA content in fine-needle aspirates of breast carcinoma.
British journal of cancer - 1 Jan 1998
Lavarino C, Corletto V, Mezzelani A, Della Torre G, Bartoli C, Riva C, Pierotti M A, Rilke F, Pilotti S
Abstract excerpt
Recent preclinical and clinical data suggest that TP53 status and TP53 mutations may be important in determining tumour aggressiveness and therapy response. In this study we investigate the feasibility of a structural and quantitative analysis of TP53 on fine-needle aspiration (FNA) material obta...
Topics
- Adult
- Aged
- Biopsy, Needle
- Breast Neoplasms
- Carcinoma
- DNA, Neoplasm
- Exons
- Female
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence
- Loss of Heterozygosity
- Middle Aged
- Mutation
- Tumor Suppressor Protein p53