Article
Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus.
The Journal of cell biology - 9 Feb 1998
Llorente A, Rapak A, Schmid S L, van Deurs B, Sandvig K
Abstract excerpt
Endocytosis and intracellular transport of ricin were studied in stable transfected HeLa cells where overexpression of wild-type (WT) or mutant dynamin is regulated by tetracycline. Overexpression of the temperature-sensitive mutant dynG273D at the nonpermissive temperature or the dynK44A mutant...
Topics
- Biological Transport
- Butyrates
- Butyric Acid
- Cell Division
- Dynamins
- Endocytosis
- Enzyme Inhibitors
- GTP Phosphohydrolases
- Golgi Apparatus
- HeLa Cells
- Histone Deacetylase Inhibitors
- Humans
- Hydroxamic Acids
- Lysosomes
- Morpholines
- Mutation
- Protein Biosynthesis
- Receptor, IGF Type 2