Article
A mutant prion protein displays an aberrant membrane association when expressed in cultured cells.
The Journal of biological chemistry - 13 Oct 1995
Lehmann S, Harris D A
Abstract excerpt
Inherited forms of prion disease have been linked to mutations in the gene encoding PrP, a neuronal and glial protein that is attached to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) anchor. One familial form of Creutzfeldt-Jakob disease is associated with a mutant PrP containing...
Topics
- Amino Acid Sequence
- Animals
- Antibodies
- Base Sequence
- CHO Cells
- Cell Membrane
- Creutzfeldt-Jakob Syndrome
- Cricetinae
- DNA Primers
- Glycosylation
- Glycosylphosphatidylinositols
- Humans
- Lipid Bilayers
- Mice
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Peptide Fragments