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Article

A mutant prion protein displays an aberrant membrane association when expressed in cultured cells.

The Journal of biological chemistry - 13 Oct 1995

Lehmann S, Harris D A

Abstract excerpt

Inherited forms of prion disease have been linked to mutations in the gene encoding PrP, a neuronal and glial protein that is attached to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) anchor. One familial form of Creutzfeldt-Jakob disease is associated with a mutant PrP containing six additional octapeptide repeats. We report here our analysis of cultured Chinese hamster ovary cells expressing a...

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Identifiers

PMID: 7592679
DOI: 10.1074/jbc.270.41.24589

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutant prion protein displays an aberrant membrane association when expressed in cultured cells.PMID 7592679Read ↗

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