Article
A protein kinase inhibitor H-7 induces process extrusion in fetal rat thyroid C-cells in vitro.
Zoological science - 1 Oct 1997
Nishiyama I, Ogiso M, Seki T, Oota T
Abstract excerpt
Calcitonin-producing cells (C-cells) are endocrine cells derived from the neural crest. We examined the effects of three types of protein kinase inhibitors on the induction of neuronal phenotypes in the rat thyroid C-cells in vitro. In a primary culture of 16-day-old fetal rat thyroid glands, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7, 25-75 microM) induced both process extrusion and...
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