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Article

Longitudinal studies on maternal HIV-1 variants by biological phenotyping, sequence analysis and viral load.

Cellular and molecular biology (Noisy-le-Grand, France) - 1 Nov 1997

Renta J Y, Cadilla C L, Vega M E, Hillyer G V, Estrada C, Jiménez E, Abreu E, Méndez I, Gandía J, Meléndez-Guerrero L M

Abstract excerpt

In this study, the HIV-1 variant viruses from ten pregnant women and their infants were isolated and characterized longitudinally in order to determine the role that viral envelope (gp120-V3 loop) gene variation and viral tropism play in vertical transmission. Biological phenotyping of each HIV variant was accomplished by growth in MT-2, and macrophages from healthy and non-HIV-infected donors. Genetic...

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PMID: 9449544

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