Article
Genetic analysis of viral variants selected in transmission of human immunodeficiency viruses to newborns.
AIDS research and human retroviruses - 1 Sept 2000
Kliks S, Contag C H, Corliss H, Learn G, Rodrigo A, Wara D, Mullins J I, Levy J A
Abstract excerpt
Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral characteristics may provide clues to the selection pressures exerted during this mode of...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- DNA, Viral
- Female
- Genetic Variation
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Infant, Newborn
- Infectious Disease Transmission, Vertical
- Molecular Sequence Data